Recent Advancement in Synthesis of Isatin as Anticonvulsant Agents: A Review

Isatin (1H-indole-2,3-dione) and its analog, are versatile substrates which acts as a precursor for large number of pharmacologically active compounds, thus having a significant importance in the synthesis of different heterocyclic compound.Isatin shows varity of biological activities such as antimicrobial, anticancer, antiviral, anticonvulsant, antiinflammatory and analgesic.This review focused on isatin synthetic methods and its biological activity as anticonvulsant. An Isatin derivative shows potent anticonvulsant activity at low concentration among all the derivatives, Schiff bases are found to be most potent anticonvulsant agent. *Corresponding author: Sumitra Nain, Department of Pharmacy, Banasthali University, Banasthali, Rajasthan-304022, India, Tel: +91-1438-228341; Extn. 348; Fax: +91-1438-228365; E-mail: [email protected] Received February 07, 2014; Accepted April 10, 2014; Published April 12, 2014 Citation: Mathur G, Nain S (2014) Recent Advancement in Synthesis of Isatin as Anticonvulsant Agents: A Review. Med chem 4: 417-427. doi:10.4172/21610444.1000173 Copyright: © 2014 Mathur G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.